The numerical modeling of cell freezing in binary solution under subcooling conditions.

Autor: Smakulski, Przemysław, Pietrowicz, Sławomir, Ishimoto, Jun
Předmět:
Zdroj: International Journal of Numerical Methods for Heat & Fluid Flow; 2020, Vol. 30 Issue 6, p3005-3025, 21p
Abstrakt: Purpose: This paper aims to describe and investigate the mathematical models and numerical modeling of how a cell membrane is affected by a transient ice freezing front combined with the influence of thermal fluctuations and anisotropy. Design/methodology/approach: The study consists of mathematical modeling, validation with an analytical solution, and shows the influence of thermal noises on phase front dynamics and how it influences the freezing process of a single red blood cell. The numerical calculation has been modeled in the framework of the phase field method with a Cahn–Hilliard formulation of a free energy functional. Findings: The results show an influence scale on directional phase front propagation dynamics and how significant are stochastic thermal noises in micro-scale freezing. Originality/value: The numerical calculation has modeled in the framework of the phase field method with a Cahn–Hilliard formulation of a free energy functional. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index