Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition.

Autor:	Kim, Min, Yin, Jun, Hwang, In Hyeok, Park, Dong Hui, Lee, Eun Kyeong, Kim, Min Ji, Lee, Min Won
Předmět:	OAK ACNE SKIN inflammation WESTERN immunoblotting ORAL mucosa
Zdroj:	Molecules; May2020, Vol. 25 Issue 9, p2154, 1p
Abstrakt:	Quercus mongolica (QM)—a member of the Fagaceae family—has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5α-reductase type 1 inhibitory activities compared with the PC, dutasteride. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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