Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis?
| Autor: | Pereira, Domingos Magno Santos, Júnior, Alexsander Rodrigues Carvalho, Lacerda, Eliza Maria da Costa Brito, Silva, Luis Cláudio Nascimento da, Marinho, Cláudio Romero Farias, André, Eunice, Fernandes, Elizabeth Soares, Carvalho Júnior, Alexsander Rodrigues, da Silva, Luis Cláudio Nascimento |
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| Předmět: |
CEREBRAL malaria
MALARIA OXIDATIVE stress MOSQUITO vectors THERAPEUTICS REACTIVE oxygen species REACTIVE nitrogen species DRUG therapy for malaria PROTOZOA RESEARCH ANIMAL experimentation RESEARCH methodology PROGNOSIS MEDICAL cooperation EVALUATION research COMPARATIVE studies ANTIMALARIALS PHARMACODYNAMICS |
| Zdroj: | Journal of Antimicrobial Chemotherapy (JAC); Jun2020, Vol. 75 Issue 6, p1363-1373, 11p |
| Abstrakt: | There is currently a global effort to reduce malaria morbidity and mortality. However, malaria still results in the deaths of thousands of people every year. Malaria is caused by Plasmodium spp., parasites transmitted through the bite of an infected female Anopheles mosquito. Treatment timing plays a decisive role in reducing mortality and sequelae associated with the severe forms of the disease such as cerebral malaria (CM). The available antimalarial therapy is considered effective but parasite resistance to these drugs has been observed in some countries. Antimalarial drugs act by increasing parasite lysis, especially through targeting oxidative stress pathways. Here we discuss the roles of reactive oxygen species and reactive nitrogen intermediates in CM as a result of host-parasite interactions. We also present evidence of the potential contribution of oxidative and nitrosative stress-based antimalarial drugs to disease treatment and control. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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