| Autor: |
Vitiello, Glauco Akelinghton Freire, de Sousa Pereira, Nathalia, Amarante, Marla Karine, Banin-Hirata, Bruna Karina, Campos, Clodoaldo Zago, de Oliveira, Karen Brajão, Losi-Guembarovski, Roberta, Watanabe, Maria Angelica Ehara |
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| Zdroj: |
Journal of Cancer Research & Clinical Oncology; Jun2020, Vol. 146 Issue 6, p1523-1532, 10p |
| Abstrakt: |
Purpose: APOBEC3A and APOBEC3B cytidine deaminases have been implicated in the pathogenesis of multiple cancers, including breast cancer (BC). A germline deletion linking APOBEC3A and APOBEC3B loci (A3A/B) has been associated with higher APOBEC-mediated mutational burden, but its association with BC risk have been controversial. Therefore, this study investigated the association between A3A/B and BC susceptibility and clinical presentation in a Brazilian cohort. Methods: A3A/B deletion was evaluated through allele-specific PCR in 341 BC patients and 397 women without familial or personal history of neoplasia from Brazil and associations with susceptibility to BC subtypes were tested through age-adjusted logistic models while correlations with clinicopathological parameters were tested using Kendall's tests. Results: No association was found between A3A/B and BC susceptibility; however, in Luminal-A BCs, it was positively correlated with tumor size (Tau-c = 0.125) and Ki67 (Tau-c = 0.116) and negatively correlated with lymph node metastasis (LNM) (Tau-c = − 0.162). The negative association between A3A/B with LNM in Luminal-A BCs remained significant even after adjusting for tumor size and Ki67 in logistic models (OR = 0.22; p = 0.008). Conclusion: These results show that although A3A/B may not modify BC susceptibility in Brazilian population, it may affect clinicopathological features in BC subtypes, promoting tumor cell proliferation while being negatively associated with LNM in Luminal-A BCs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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