Ligand-Free and Solvent-Free Synthesis of 1,3-Disubstituted Naphthalenes through Stille Coupling.

Autor: Sbi, Sanae, Mkpenie, Victor, Tanemura, Kiyoshi, Rohand, Taoufik
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Zdroj: Synlett; 2020, Vol. 31 Issue 9, p903-906, 4p
Abstrakt: A variety of 1,3-disubstituted naphthalenes have been prepared by palladium-catalyzed annulation of (o -ethynylphenyl)acetyl chloride with design of a new synthetic strategy by Stille coupling using functionalized organostannanes. The method affords excellent yields of the substituted naphthalenes and accommodates a wide variety of functional groups under mild conditions. Mechanistic studies show intramolecular cyclization as a major step following C–C bond coupling. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index