| Autor: |
Pereira, Treville, Surve, Ridima, Shetty, Subraj, Gotmare, Swati |
| Předmět: |
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| Zdroj: |
Journal of Oral & Maxillofacial Pathology (0973029X); Jan-Apr2020, Vol. 24 Issue 1, p106-112, 7p |
| Abstrakt: |
Background: Oral submucous fibrosis (OSF) is a precancerous condition predominantly seen in people of Asian descent. About 7%–12% of OSF patients develop oral squamous cell carcinoma. Morphological features of OSF, especially fibrosis, suggest a possibility of hypoxic environment in diseased tissues. Neovascularization and increased glycolysis, represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion and metastasis. The adaptation of cells to hypoxia appears to be mediated through hypoxia-inducible factor-1α (HIF-1α). HIF-1α is said to be associated with malignant transformation of epithelium in other sites. Aim: The aim of this study was to investigate the relationship between the expression of HIF-1α in OSMF and its role in malignant transformation. Materials and Methods: A retrospective study which included 20 histopathologically diagnosed cases of OSF was conducted. A qualitative evaluation of HIF-1α was performed. Statistical analysis was carried out using the IBM Statistical Package for Social Sciences 20.0 version (IBM Corporation, Armonk, NY, USA). Results: Results showed an increased expression of HIF-1α in OSF. Conclusion: HIF-1α appears to play a role in malignant transformation of OSF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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