| Autor: |
Lee, J, Eley, VA, Wyssusek, KH, Kimble, RMN, Way, M, Coonan, E, Cohen, J, Rowell, J, Zundert, AA, Eley, V A, Wyssusek, K H, van Zundert, A A |
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| Zdroj: |
BJOG: An International Journal of Obstetrics & Gynaecology; Jun2020, Vol. 127 Issue 7, p820-827, 8p, 1 Diagram, 4 Charts |
| Abstrakt: |
Objective: The aim of this study was to establish rotational thromboelastometry (ROTEM® ) baseline parameters in labouring women at term gestation. The secondary aim was to compare these reference ranges with those from previous studies on labouring women and from the manufacturer.Design: A prospective, observational study.Setting: Tertiary referral hospital.Participants: Healthy women in labour.Methods: Ethics approval was granted for an opt-out recruitment approach. ROTEM® testing was performed in labouring women at term gestation. Women with any condition affecting coagulation were excluded. ROTEM® Delta reference ranges were derived by calculating the 2.5% and 97.5% centiles for INTEM/EXTEM/FIBTEM parameters including amplitude at 5 minutes (A5), coagulation time (CT) and maximum clot firmness (MCF).Main Outcome Measures: ROTEM® parameters were measured in labouring women before delivery. The following tests were performed: FIBTEM, EXTEM and INTEM.Results: One hundred and twenty-one women met the inclusion criteria, with a mean (± SD) age of 29.6 ± 5.4 years and median (interquartile range) gestation of 39.4 weeks (37.4-40.4 weeks). Seventy-five (62.0%) women were nulliparous and 71 (58.7%) delivered vaginally. The median and interquartile ranges for selected ROTEM® parameters were: FIBTEM A5, 21 mm (IQR 18-23 mm); EXTEM A5, 55 mm (52-58 mm); and EXTEM CT, 52 seconds (48-56 seconds).Conclusions: The FIBTEM/EXTEM/INTEM amplitudes were higher than the manufacturer's reference ranges for non-obstetric patients. The FIBTEM MCF upper and lower limits were higher and the EXTEM/INTEM CT was shorter and narrower in range. This study provides reference ranges for ROTEM® values in healthy labouring women at term gestation with uncomplicated pregnancies.Tweetable Abstract: This is the first study to report on ROTEM® reference ranges with over 120 healthy labouring women of normal weight at term gestation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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