| Abstrakt: |
Background: Thyroid gland is one of most important gland in the body, function mainly through synthesis of thyroid hormones. The gland influences almost all of the metabolic processes in the body.Epilepsy is a complicated condition that may affect different areas of human life. Epileptic seizures change the endocrine environment mainly through the action on the hypothalamic-pituitary axis. The gland function could be affected by many disorders and drugs. Objectives: To assess thyroid function test abnormality in patients using Sodium valproate. Patient and Method: A case – control study conducted at Al Yarmouk teaching hospital for 50 patients with generalized epilepsy who attend neurological clinic from January 2015 to November 2015.From each a detailed history and examination had been taken age, sex, bodymass index, duration of treatment and dose of each one. Inclusion criteria: patients presented with idiopathic generalized epilepsy receiving sodium valproate tablet twice daily with different total dose without any other drugs. Patient with disease other than epilepsy is excluded. Also 50 controls have no any chronic disease [hypertension, diabetes, kidney disease or drugs affecting thyroid or history of thyroid surgery, no smoking or alcoholic]. Blood samples were sent for TSH, T3, T4, f T3, f T4 in Al Yarmouk teaching hospital laboratory to assess thyroid function abnormality in these patients and compared with the general population. Finding :50 patients with generalized epilepsy receiving sodium valproate who complete study 26 were female and 24 were male, their ages were ranged between 14and 51 year old, subclinical hypothyroidism were seen in [10 / 50] 20% of patients and [3/50] 6% of control in this study . The comparison with the control group showed significant statistical difference. Conclusion: The percentage of subclinical hypothyroidism is significant in patient using Sodium valproate. [ABSTRACT FROM AUTHOR] |
