Innovative Burn Treatment Using Tilapia Skin as a Xenograft: A Phase II Randomized Controlled Trial.
| Autor: | Júnior, Edmar Maciel Lima, Filho, Manoel Odorico De Moraes, Costa, Bruno Almeida, Rohleder, Andréa Vieira Pontes, Rocha, Marina Becker Sales, Fechine, Francisco Vagnaldo, Forte, Antonio Jorge, Alves, Ana Paula Negreiros Nunes, Júnior, Francisco Raimundo Silva, Martins, Camila Barroso, Mathor, Mônica Beatriz, Moraes, Maria Elisabete Amaral de, Lima Júnior, Edmar Maciel, De Moraes Filho, Manoel Odorico, Sales Rocha, Marina Becker, Silva Júnior, Francisco Raimundo |
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| Předmět: |
TILAPIA
BIOLOGICAL dressings NILE tilapia SKIN SILVER sulfadiazine WOUND healing TREATMENT for burns & scalds RESEARCH XENOGRAFTS PAIN measurement ARTIFICIAL skin ANIMAL experimentation RESEARCH methodology MEDICAL cooperation EVALUATION research OCCLUSIVE surgical dressings BODY surface area COMPARATIVE studies FISHES |
| Zdroj: | Journal of Burn Care & Research; May/Jun2020, Vol. 41 Issue 3, p585-592, 8p |
| Abstrakt: | Skin substitutes are considered a useful alternative for occlusive dressings in the treatment of superficial burns as they reduce the frequency of dressing replacement. This phase II randomized controlled trial aimed to evaluate the efficacy of Nile tilapia (Oreochromis niloticus) skin as an occlusive xenograft dressing for the treatment of burn wounds in humans. In order to assess the use of tilapia skin, the following variables were evaluated: number of days for wound healing, the number of times the occlusive dressing was changed, use of anesthetics or analgesics, pain assessment using the Visual Analogue Scale, and evaluation of burn improvement on the day of dressing removal. In total, 62 participants completed the study. It was found that in participants treated with tilapia skin, complete reepithelialization occurred in significantly fewer days; reported pain intensity was lower (study arms B and C), the amount of anesthetics/analgesics required was lower (study arms B and C), and the necessity of dressing changes was significantly reduced in comparison with volunteers treated with silver sulfadiazine. In our study, the tilapia skin xenograft showed good efficacy as an occlusive biological dressing for burn wound treatment in humans. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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