| Autor: |
Matte, Catherine C., Jinli Liu, Cormier, James, Anderson, Britt E., Athanasiadis, Ioanna, Jain, Dhanpat, McNiff, Jennifer, Shlomchik, Warren D. |
| Předmět: |
|
| Zdroj: |
Nature Medicine; Sep2004, Vol. 10 Issue 9, p987-992, 6p |
| Abstrakt: |
Graft-versus-host disease (GVHD) is a major source of morbidity in allogenic stem cell transplantation¹. We previously showed that recipient antigen-presenting cells (APCs) are required for CD8-dependent GVHD in a mouse model across only minor histocompatibility antigens (minor H antigens)². However, these studies did not address the function of donor-derived APCs after GVHD is initiated. Here we show that GVHD develops in recipients of donor major histocompatibility complex class I-deficient (MHC I¯) bone marrow. Thus, after initial priming, CD8 cells caused GVHD without a further requirement for hematopoietic APCs, indicating that host APCs are necessary and sufficient for GHVD. Nonetheless, GVHD was less severe in recipients of MHC I¯ bone marrow. Therefore, once initiated, GVHD is intensified by donor-derived cells, most probably donor APCs cross-priming alloreactive CD8 cells. Nevertheless, donor APCs were not required for CDS-mediated graft-versus-leukemia (GVL) against a mouse model of chronic-phase chronic myelogenous leukemia. These studies identify donor APCs as a new target for treating GVHD, which may preserve GVL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
