| Autor: |
Rueda, B., Martinez, A., López-Nevot, M.A., Mas-Fontao, A., Paco, L., Ortega, E., Fernández-Arquero, M., Urcelay, E., Gomez De La Concha, E., Martín, J. |
| Předmět: |
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| Zdroj: |
Genes & Immunity; Oct2004, Vol. 5 Issue 6, p517-519, 3p |
| Abstrakt: |
In coeliac disease (CD) a profile of proinflammatory cytokines are secreted interferon gamma (IFN?) being one of the most important. A dinucleotide polymorphism consisting of a variable number of CA repeats related with IFN?production levels, has been reported on the first intron of the IFN?gene. The aim of this study was to analyse the influence of the functional IFN?CA repeats in CD predisposition through familial and case-control studies. The familial analysis showed that the 124?bp allele was significantly more transmitted to the affected offspring (P=0.02), while the 126?bp allele showed a statistically significant nontransmission pattern (P=0.01). Nevertheless, in the case-control analysis, we could not find a direct association of CA repeats with CD. This fact might be due to parent-of-origin effect in the IFN?CA polymorphism. Our data suggest a possible role of IFN?CA polymorphism in CD susceptibility.Genes and Immunity (2004) 5, 517-519. doi:10.1038/sj.gene.6364115 Published online 24 June 2004 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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