| Autor: |
Pinheiro, Paulo S., Medina, Heidy N., Callahan, Karen E., Jones, Patricia D., Brown, Clyde P., Altekruse, Sean F., McGlynn, Katherine A., Kobetz, Erin N. |
| Předmět: |
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| Zdroj: |
Liver International; May2020, Vol. 40 Issue 5, p1201-1210, 10p, 5 Charts, 1 Graph |
| Abstrakt: |
Background and Aim: The incidence of hepatocellular carcinoma (HCC) has risen considerably in the US since 1980. The main causes include metabolic disorders (NAFLD, diabetes, obesity, metabolic syndrome), alcohol‐related disease (ALD) and hepatitis C and B virus infections (HCV, HBV). Etiology‐specific HCC incidence rates by detailed race‐ethnicity are needed to improve HCC control and prevention efforts. Methods: All HCC cases diagnosed in Florida during 2014‐2015 were linked to statewide hospital discharge data to determine etiology. Age‐specific and age‐adjusted rates were used to assess the intersection between etiology and detailed racial‐ethnicities, including White, African American, Afro‐Caribbean, Asian, Cuban, Puerto Rican and Continental Hispanic (Mexican, South and Central American). Results: Of 3666 HCC cases, 2594 matched with discharge data. HCV was the leading cause of HCC among men and women (50% and 43% respectively), followed by metabolic disorders (25% and 37%) and ALD (16% and 9%). Puerto Rican and African American men had the highest HCV‐HCC rates, 7.9 and 6.3 per 100 000 respectively. Age‐specific rates for HCV‐HCC peaked among baby boomers (those born in 1945‐1965). Metabolic‐HCC rates were highest among populations above age 70 and among Continental Hispanics. Afro‐Caribbean men had high rates of HBV‐HCC, whereas Puerto Rican men had high ALD‐HCC. Conclusions: HCC etiology is associated with specific race/ethnicity. While HCV‐related HCC rates are projected to decrease soon, HCC will continue to affect Hispanics disproportionately, based on higher rates of metabolic‐HCC (and ALD‐HCC) among Continental Hispanics, who demographically represent 80% of all US Hispanics. Multifaceted approaches for HCC control and prevention are needed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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