| Autor: |
Islam, Fahadul, Azad, A. K., Faysal, Md., Azad, Md. A. K., Islam, Saiful, Amin, Md. Al, Sultana, Nahida, Dola, Farhana Yeasmen, Rahman, Md. Mominur, Alam Begh, Md. Zamshed |
| Předmět: |
|
| Zdroj: |
Journal of Drug Delivery & Therapeutics; 2020 Supplement, Vol. 10, p62-65, 4p |
| Abstrakt: |
Objectives: Present study was designed to evaluate Analgesic, Antidiarrhoeal and Antimicrobial activities of methanol and acetone extracts of fruit peels of Limonia acidissima L. by different methods. Method: The analgesic activity of the samples was studied using acetic acid- induced writhing model in mice. Castor oil-induced antidiarrheal activity was observed by Thomas method and antimicrobial activity was monitored by disc diffusion method. Results: Limonia acidissima L. inhibited 60.53 % and 59.65 % writhing of methanol as well as acetone fruit peels extracts, respectively, compared to standard drug Diclofenac Na inhibited 78.07 % writhing. At higher dose (500 mg/kg) of the methanol and acetone fruit peels extracts, significant inhibition 47.13 and 44.83 % of characteristic diarrhoeal feces was observed, respectively, as well as at lower dose (250 mg/kg) of the both extracts, inhibition 34.45 and35.63 %. Mention able on average 12mm zone of inhibition was observed of both extract at 250μg/disc and 500μg/disc compare to zone of inhibition 36mm of ciprofloxacin at 50μg/disc. Conclusion: From the above results, it will be very much possible source for an isolating lead compound for curing the numerous disorders. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
