| Autor: |
Gröschel, Matthias I., Meehan, Conor J., Barilar, Ivan, Diricks, Margo, Gonzaga, Aitor, Steglich, Matthias, Conchillo-Solé, Oscar, Scherer, Isabell-Christin, Mamat, Uwe, Luz, Christian F., De Bruyne, Katrien, Utpatel, Christian, Yero, Daniel, Gibert, Isidre, Daura, Xavier, Kampmeier, Stefanie, Rahman, Nurdyana Abdul, Kresken, Michael, van der Werf, Tjip S., Alio, Ifey |
| Předmět: |
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| Zdroj: |
Nature Communications; 4/27/2020, Vol. 11 Issue 1, p1-12, 12p |
| Abstrakt: |
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals. Multidrug resistance of the opportunistic pathogen Stenotrophomonas maltophilia is an increasing problem. Here, analyzing strains from 22 countries, the authors show that the S. maltophilia complex is divided into 23 monophyletic lineages and find evidence for intra-hospital transmission. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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