| Autor: |
Ye, Christine J., Chen, Jason, Liu, Guo, Heng, Henry H. |
| Předmět: |
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| Zdroj: |
Frontiers in Genetics; 4/22/2020, Vol. 11, p1-5, 5p |
| Abstrakt: |
Keywords: cellular heterogeneity; fuzzy inheritance; genome chaos; genome theory; macro-cellular evolution; two phases of cancer evolution; karyotype coding; system inheritance EN cellular heterogeneity fuzzy inheritance genome chaos genome theory macro-cellular evolution two phases of cancer evolution karyotype coding system inheritance 1 5 5 04/24/20 20200422 NES 200422 Background Somatic genomic mosaicism occurs when somatic cells of the body display different genotypes (Table 1), it has recently received increased attention because of its implications in disease, including neurodegenerative diseases and Down syndrome (Iourov et al., [24], [25], [26]; Biesecker and Spinner, [5]; Hultén et al., [23]; Vijg, [45]; Campbell et al., [8]; Fernández et al., [12]). Here, "somatic mosaicism" rather than "genomic heterogeneity" is used to promote the exchangeable use of these two terms in cancer research. |
| Karyotype coding vs. gene coding Karyotype coding is responsible for passing system inheritance, while gene coding determines parts inheritance (Ye et al., 2019b). The two-phased cancer evolution pattern also challenges the general assumption that the accumulation of microevolution over time leads to macroevolution (Heng, 2015, 2019). |
| Genome chaos vs. chromothripsis Genome chaos or karyotype chaos refers to a phenomenon of rapid and massive genome re-organization. Cellular heterogeneity, fuzzy inheritance, genome chaos, genome theory, macro-cellular evolution, two phases of cancer evolution, karyotype coding, system inheritance. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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