IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids.

Autor: Dijk, F. Nicole, Vijverberg, Susanne J., Hernandez‐Pacheco, Natalia, Repnik, Katja, Karimi, Leila, Mitratza, Marianna, Farzan, Niloufar, Nawijn, Martijn C., Burchard, Esteban G., Engelkes, Marjolein, Verhamme, Katia M., Potočnik, Uroš, Pino‐Yanes, Maria, Postma, Dirkje S., Maitland‐van der Zee, Anke‐Hilse, Koppelman, Gerard H.
Předmět:
Zdroj: Allergy; Apr2020, Vol. 75 Issue 4, p984-989, 6p, 1 Chart, 1 Graph
Abstrakt: To the editor, Asthma, one of the most common chronic diseases in childhood, is caused by interactions between genes and environmental factors. Since the IL-33/IL1RL1 pathway has been associated with eosinophilic, type 2, inflammation, we hypothesized that I IL1RL1 i SNPs may affect corticosteroid treatment response in asthma patients. No association between I IL1RL1 i and questionnaire-based asthma control was found. [Extracted from the article]
Databáze: Complementary Index