Nontuberculous mycobacterial infections in a Brazilian pediatric population: a seven-year survey.

Autor: Mauch, Renan M., Mansinho, Andrea A.S., Rocha, Priscilla M.O., Zaccariotto, Tânia R., Levy, Carlos E., Nolasco da Silva, Marcos T.
Zdroj: Pathogens & Global Health; Mar2020, Vol. 114 Issue 2, p104-108, 5p
Abstrakt: The aim of this study was to describe the frequency of nontuberculous mycobacteria (NTM) isolation and their related outcomes among pediatric patients of a Brazilian university hospital from 2012 to 2019. NTM were identified in different clinical samples by microbiological culture and molecular-based methods. NTM were isolated from 14 patients, out of whom four (27%) were infected and were treated accordingly. Two were infected with Mycobacterium avium complex (MAC), two with M. abscessus complex (MABSC) and one with M. intracellulare. Two patients had cystic fibrosis-related lung disease and improved after successful NTM eradication. One patient was HIV-positive and died. One patient had severe combined immunodeficiency (SCID)-related pneumonia and is currently being followed-up. We conclude that NTM frequency in our center was low among pediatric patients. Whether this is inherent to Brazilian patients, due to the broad coverage of the Bacille Calmette-Guérin (BCG) vaccine in Brazil, or a result of underdiagnosis remains to be elucidated. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index