Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop.

Autor: Campbell, J. Darren, Gangur, Venu, Simons, F. Estelle R., Hayglass, Kent T.
Předmět:
Zdroj: FASEB Journal; Feb2004, Vol. 18 Issue 2, p329-311, 3p, 1 Diagram, 2 Graphs
Abstrakt: Presents findings of a study which tested the hypothesis that exogenous CXCR3 ligands CXCL9, CXCL10 and CXCL11 directly promote allergen-selective enhancements in Th-1 recall immune responses in allergic individuals. Role of CXCL10 chemokine in enhancing interferonϒ production; Reponse of allergic individuals to allergens mediated by Th2 cytokines or interleukin-10; Relationship between CXCR3 expression on peripheral blood CD4+/CD45RO+ cells.
Databáze: Complementary Index