| Autor: |
Sakaue, Saori, Hirata, Jun, Kanai, Masahiro, Suzuki, Ken, Akiyama, Masato, Lai Too, Chun, Arayssi, Thurayya, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K., Halabi, Hussein, Badsha, Humeira, Uthman, Imad W., Saxena, Richa, Padyukov, Leonid, Hirata, Makoto, Matsuda, Koichi, Murakami, Yoshinori, Kamatani, Yoichiro, Okada, Yukinori |
| Předmět: |
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| Zdroj: |
Nature Communications; 3/26/2020, Vol. 11 Issue 1, p1-11, 11p |
| Abstrakt: |
The diversity in our genome is crucial to understanding the demographic history of worldwide populations. However, we have yet to know whether subtle genetic differences within a population can be disentangled, or whether they have an impact on complex traits. Here we apply dimensionality reduction methods (PCA, t-SNE, PCA-t-SNE, UMAP, and PCA-UMAP) to biobank-derived genomic data of a Japanese population (n = 169,719). Dimensionality reduction reveals fine-scale population structure, conspicuously differentiating adjacent insular subpopulations. We further enluciate the demographic landscape of these Japanese subpopulations using population genetics analyses. Finally, we perform phenome-wide polygenic risk score (PRS) analyses on 67 complex traits. Differences in PRS between the deconvoluted subpopulations are not always concordant with those in the observed phenotypes, suggesting that the PRS differences might reflect biases from the uncorrected structure, in a trait-dependent manner. This study suggests that such an uncorrected structure can be a potential pitfall in the clinical application of PRS. Population structure, even subtle differences within seemingly homogenous populations, can have an impact on the accuracy of polygenic prediction. Here, Sakaue et al. use dimensionality reduction methods to reveal fine-scale structure in the Biobank Japan cohort and explore the performance of polygenic risk scores. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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