Assessment of gait parameters and physical function in patients with advanced cancer participating in a 12‐week exercise and nutrition programme: A controlled clinical trial.
| Autor: | Schink, Kristin, Gaßner, Heiko, Reljic, Dejan, Herrmann, Hans J., Kemmler, Wolfgang, Schwappacher, Raphaela, Meyer, Julia, Eskofier, Björn M., Winkler, Jürgen, Neurath, Markus F., Klucken, Jochen, Zopf, Yurdagül |
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ANTHROPOMETRY
BODY composition C-reactive protein CANCER patients CHI-squared test CLINICAL trials DIAGNOSIS ELECTRIC stimulation EMOTIONS EXERCISE therapy FISHER exact test GAIT disorders GAIT in humans GRIP strength NUTRITION HEALTH outcome assessment PHYSICAL therapy QUESTIONNAIRES RESEARCH funding T-test (Statistics) WEARABLE technology PILOT projects EVALUATION of human services programs DATA analysis software FUNCTIONAL assessment DESCRIPTIVE statistics KARNOFSKY Performance Status MANN Whitney U Test |
| Zdroj: | European Journal of Cancer Care; Mar2020, Vol. 29 Issue 2, p1-13, 13p, 1 Diagram, 5 Charts |
| Abstrakt: | Objective: Gait is a sensitive marker for functional declines commonly seen in patients treated for advanced cancer. We tested the effect of a combined exercise and nutrition programme on gait parameters of advanced‐stage cancer patients using a novel wearable gait analysis system. Methods: Eighty patients were allocated to a control group with nutritional support or to an intervention group additionally receiving whole‐body electromyostimulation (WB‐EMS) training (2×/week). At baseline and after 12 weeks, physical function was assessed by a biosensor‐based gait analysis during a six‐minute walk test, a 30‐s sit‐to‐stand test, a hand grip strength test, the Karnofsky Index and EORTC QLQ–C30 questionnaire. Body composition was measured by bioelectrical impedance analysis and inflammation by blood analysis. Results: Final analysis included 41 patients (56.1% male; 60.0 ± 13.0 years). After 12 weeks, the WB‐EMS group showed higher stride length, gait velocity (p <.05), six‐minute walking distance (p <.01), bodyweight and skeletal muscle mass, and emotional functioning (p <.05) compared with controls. Correlations between changes in gait and in body composition, physical function and inflammation were detected. Conclusion: Whole‐body electromyostimulation combined with nutrition may help to improve gait and functional status of cancer patients. Sensor‐based mobile gait analysis objectively reflects patients' physical status and could support treatment decisions. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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