| Autor: |
Svedmyr, Karin, Löfdahl, Claes-Göran, Svedmyr, Nils |
| Předmět: |
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| Zdroj: |
Allergy; Jan1984, Vol. 39 Issue 1, p17-22, 6p |
| Abstrakt: |
Seven asthmatic patients were studied in a single-blind randomized, crossover study after oral administration of 20 mg nifedipine or placebo Four increasing doses of i.v. terbutaline were then given with 30 min interval. The study was concluded with inhalation of five terbutaline puffs. FEVI measurements 30 min after intake of nifedipine did not show any difference compared to placebo. During the terbutaline treatment, however there was a more pronounced bronchodilation after nifedipine than after placebo (P < 0.05). Terbutaline-induced skeletal muscle tremor was similar after nifedipine and placebo pretreatment's After nifedipine intake there was a decrease of diastolic blood pressure and a reflexogenic tachycardia. Thus, this study showed a small potendation of the beta2-adrenoceptor mediated bronchodilation, which is of importance when treating patients with simultaneous asthma and hypertension or angina pectoris. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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