BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing.

Autor:	Rinonce, Hanggoro Tri, Aji, Rovi Panji Mustiko, Hayati, Ni'mah, Pudjohartono, Maria Fransiska, Kameswari, Bidari, Anwar, Sumadi Lukman, Irianiwati
Předmět:	MELANOMA PYROSEQUENCING CYCLIN-dependent kinase inhibitor-2A SKIN GENE frequency SKIN cancer
Zdroj:	BMC Research Notes; 3/18/2020, Vol. 13 Issue 1, p1-5, 5p, 1 Chart, 1 Graph
Abstrakt:	Objective: We aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia using pyrosequencing. Results: BRAF V600 mutations of the V600E type were found in 21 (53.85%) specimens. The variant allele frequencies (VAFs) ranged from 5.07 to 94.70%, averaging 29.05%. However, most cases had low VAFs, with 13 (61.9%) specimens below 20% and 4 (19.05%) below 10%. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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