Contribution of Congenital Cytomegalovirus Infection to Permanent Hearing Loss in a Highly Seropositive Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study.

Autor:	Yamamoto, Aparecida Y, Anastasio, Adriana R T, Massuda, Eduardo T, Isaac, Myriam L, Manfredi, Alessandra K S, Cavalcante, Juliana M S, Carnevale-Silva, Adriana, Fowler, Karen B, Boppana, Suresh B, Britt, William J, Mussi-Pinhata, Marisa M
Předmět:	DEAFNESS prevention HEARING disorder diagnosis COMMUNICABLE disease epidemiology AGE distribution AGE factors in disease AUDIOMETRY CONFIDENCE intervals COST effectiveness CYTOMEGALOVIRUS diseases HEARING disorders INTEGRATED health care delivery MATERNAL health services PREGNANCY complications TIME AT-risk people DISEASE prevalence DESCRIPTIVE statistics MIXED infections DISEASE complications DISEASE risk factors CHILDREN
Zdroj:	Clinical Infectious Diseases; Apr2020, Vol. 70 Issue 7, p1379-1384, 6p
Abstrakt:	Background The exact contribution of congenital cytomegalovirus infection (cCMVI) to permanent hearing loss (HL) in highly seropositive populations is unknown. We determined the contribution of cCMVI to HL and estimated the effectiveness of newborn hearing screening (HS) in identifying neonates with CMV-related HL. Methods A total of 11 900 neonates born from a population with ≥97% maternal seroprevalence were screened for cCMVI and HL. cCMVI was confirmed by detection of CMV-DNA in saliva and urine at age <3 weeks. Results Overall, 68 (0.6%; 95% confidence interval [CI], 0.4–0.7) neonates were identified with cCMVI. Of the 91 (0.8%) newborns who failed the HS, 24 (26.4%) were confirmed with HL, including 7 (29.2%; 95% CI, 17.2–59.3) with cCMVI. Another newborn with cCMVI passed the HS but was confirmed with HL at age 21 days. Of the 62 neonates with cCMVI who underwent a complete hearing evaluation, 8 (12.9%; 95% CI, 6.7–23.4) had HL and most (7/8; 87.5%; 95% CI, 46.6–99.7) were identified by HS. The rate of CMV-related HL was 8 per 11 887 neonates (0.7 per 1000 live births). The prevalence ratio of HL among neonates with cCMVI compared to CMV-uninfected neonates was 89.5 (95% CI, 39.7–202.0). No late-onset cCMVI-related HL was detected during a median follow-up of 36 months. Conclusions cCMVI is an important cause of HL in childhood in all settings. Integrating targeted cCMVI screening among neonates who fail a HS could be a reasonable, cost-effective strategy to identify newborns with early-onset cCMVI-related HL. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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