| Autor: |
Resendez, Shanna L., Namboodiri, Vijay Mohan K., Otis, James M., Eckman, Louisa E. H., Rodriguez-Romaguera, Jose, Ung, Randall L., Basiri, Marcus L., Kosyk, Oksana, Rossi, Mark A., Dichter, Gabriel S., Stuber, Garret D. |
| Předmět: |
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| Zdroj: |
Journal of Neuroscience; 3/11/2020, Vol. 40 Issue 11, p2282-2295, 14p |
| Abstrakt: |
Oxytocin (OT) is critical for the expression of social behavior across a wide array of species; however, the role of this system in the encoding of socially relevant information is not well understood. In the present study, we show that chemogenetic activation of OT neurons within the paraventricular nucleus of the hypothalamus (PVH) of male mice (OT-Ires-Cre) enhanced social investigation during a social choice test, while chemogenetic inhibition of these neurons abolished typical social preferences. These data suggest that activation of the OT system is necessary to direct behavior preferentially toward social stimuli. To determine whether the presence of a social stimulus is sufficient to induce activation of PVH-OT neurons, we performed the first definitive recording of OT neurons in awake mice using two-photon calcium imaging. These recordings demonstrate that social stimuli activate PVH-OT neurons and that these neurons differentially encode social and nonsocial stimuli, suggesting that PVH-OT neurons may act to convey social salience of environmental stimuli. Finally, an attenuation of social salience is associated with social disorders, such as autism. We therefore also examined possible OT system dysfunction in a mouse model of autism, Shank3b knock-out (KO) mice. Male Shank3b KO mice showed a marked reduction in PVH-OT neuron number and administration of an OT receptor agonist improved social deficits. Overall, these data suggest that the presence of a social stimulus induces activation of the PVH-OT neurons to promote adaptive social behavior responses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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