Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

Autor: Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F., Zevallos, Jose P., Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M., Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia S. A., Turati, Federica
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Zdroj: British Journal of Cancer; Mar2020, Vol. 122 Issue 6, p745-748, 4p, 1 Chart
Abstrakt: High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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