The Relationships of High-Sensitivity C-Reactive Protein and Homocysteine Levels With Disease Activity, Damage Accrual, and Cardiovascular Risk in Systemic Lupus Erythematosus.
Autor: | Pocovi-Gerardino, Gabriela, Correa-Rodríguez, Maria, Rubio, José-Luis Callejas, Fernández, Raquel Ríos, Amada, María Martín, Caparros, María-Gracia Cruz, Rueda-Medina, Blanca, Ortego-Centeno, Norberto |
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Předmět: |
C-reactive protein
CARDIOVASCULAR diseases risk factors CONFIDENCE intervals DIABETES HYPERTENSION LIPIDS LOW density lipoproteins OBESITY REGRESSION analysis SYSTEMIC lupus erythematosus HOMOCYSTEINE COMORBIDITY CROSS-sectional method ANKLE brachial index DATA analysis software DESCRIPTIVE statistics |
Zdroj: | Biological Research for Nursing; Apr2020, Vol. 22 Issue 2, p169-177, 9p |
Abstrakt: | Chronic inflammation coupled with cardiovascular disease (CVD) risk factors influences the progression of atherosclerosis in systemic lupus erythematosus (SLE). High-sensitivity C-reactive protein (hs-CRP) and homocysteine (Hcy) are associated with the risk of CVD in the general population, but their associations with CV risk and disease activity in SLE are unclear. In this cross-sectional study (N = 139 SLE patients, mean age = 45.27 ± 13.18 years), we investigated associations between hs-CRP and Hcy levels and disease activity, damage accrual, and CVD risk in SLE. Disease activity and damage accrual were measured with the SLE Activity Index 2000 (SLEDAI-2K), the Systemic Lupus Erythematosus International Collaborating Clinics Group/American College of Rheumatology damage index (SDI), and anti-double-stranded DNA antibodies (anti-dsDNA). CVD risk factors of obesity, diabetes mellitus, hypertension, blood lipids, and ankle–brachial index were collected. Linear regression analysis and one-way analysis of variance were used to analyze relationships of hs-CRP and Hcy with SLE activity, damage accrual, and CVD risk factors. Results: hs-CRP correlated significantly with SLEDAI-2K (p =.036), SDI (p =.00), anti-dsDNA titers (p =.034), diabetes (p =.005), and obesity (p =.027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p =.032 and p <.001, respectively), TG/high-density lipoprotein cholesterol index (p =.020 and p =.001, respectively), and atherogenic index of plasma (p =.006 and p =.016, respectively). hs-CRP levels >3 mg/L correlated with SDI score (p =.012) and several CVD risk factors. Discussion: Findings suggest SLE patients with elevated hs-CRP and/or Hcy have a higher prevalence of CVD risk factors. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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