Effect of anti-IgE antibodies on IgE binding to CD23.

Autor:	Nakajima, K., de Weck, A. L., Stadler, B. M.
Předmět:	ANTI-immunoglobulin E autoantibodies IMMUNOGLOBULINS LYMPHOBLASTOID cell lines HISTAMINE LEUCOCYTES ANTIGENS
Zdroj:	Allergy; Apr89, Vol. 44 Issue 3, p187-191, 5p
Abstrakt:	Human sera contain anti-IgE autoantibodies. Using a human B lymphoblastoid cell line (Wil-2WT cells) and monoclonal murine anti-IgE antibodies (BSW17 and Le27) We investigated a possible role of such anti-IgE antibodies. A 100-fold excess of monoclonal anti-IgE antibodies inhibited binding of 125I labeled IgE to Fc∊RII on Wil-2WT cells. Further, both monoclonal anti-IgE antibodies dissociated surface bound IgE from Fc∊RII on Wil-2WT cells. However, BSW17 which does not trigger histamine release from human leucocytes, was much more effective in dissociating Fc∊RII bound IgE than Le27 which triggers histamine release. These results may suggest that naturally occurring IgG anti-IgE antibodies are able to inhibit binding of IgE to its receptor. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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