| Autor: |
Gad, Mai, Abou-Bakr, Amany, Mohamed, Ghada, Nassar, Hanan Ramdan, Ibraheem, Maher H., Talima, Soha, Allam, Rasha Mahmoud |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Jan2020, Vol. 11 Issue 1, p1712-1718, 7p |
| Abstrakt: |
We aimed in this study to detect the correlation between PD-L1 and TILs, and their relationship with clinical outcome and survival in Egyptian patients with HGSOC. Immunohistochemical expression of PD-L1, CD4 and CD8 was investigated in 94 HGSOC Egyptian patients. PD-L1 immunoreactivity was detected in 24% of the cases. The lack of tumor PD-L1 expression proved to be an independent predictive factor for better overall survival (OS) (p= 0.01). Moreover, high stromal CD8+ TILs density had a significant impact on better disease-free survival (p=0.007). Patients who showed negative expression of PD-L1 and high intraepithelial CD8+ TILs density lived significantly longer than other patients (p- 0.021). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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