| Autor: |
Singh, Rahul, Hembrom, Ashish, Goswami, Raksha, Kumawat, Deepak |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery & Therapeutics; Jan/Feb2020, Vol. 10 Issue 1A, p68-68, 1p |
| Abstrakt: |
The concept of floating drug delivery system is described in the 1968. FDDS of microsphere is the novel drug delivery system. Floating drug delivery system of microsphere have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Several approaches have been used to retain the dosage form in stomach as a way of enhancing the gastric residence time which includes floatation systems, high-density systems, mucoadhesive systems or swellable systems and superporous hydrogel are novel drug delivery system to maximize efficiency of drug. The attention behind floating microspheres is due to the uniformity of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. These systems have more benefits over the single unit dosage forms. Microspheres are free flowing powders made up of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. Microspheres have high loading capacity and many polymers have been used such as albumin, gelatin, starch, polymethacrylate, polyacrylamine, and polyalkylcyanoacrylate. The gastroretentive dosage form resides in the stomach for longer period of time than predictable dosage forms. These systems provide tremendous opportunities in the design of new controlled and delayed release oral formulations, thus extending of futuristic pharmaceutical development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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