| Autor: |
Yasuda, Tadahito, Eto, Kojiro, Yoshida, Naoya, Iwagami, Shiro, Hiyoshi, Yukiharu, Nagai, Youhei, Iwatsuki, Masaaki, Ishimoto, Takatsugu, Baba, Yoshifumi, Miyamoto, Yuji, Shiota, Takuya, Mikami, Yoshiki, Baba, Hideo |
| Předmět: |
|
| Zdroj: |
Surgical Case Reports; 3/7/2020, Vol. 6 Issue 1, p1-4, 4p |
| Abstrakt: |
Background: To date, only a few cases of multiple GISTs with different clones in different organs have been published. However, a case of multiple GISTs with different clones occurring in a single organ has never been reported. Case presentation: A 41-year-old patient underwent laparoscopic partial gastrectomy for gastric gastrointestinal stromal tumor (GIST) in 2012. The pathological findings showed high-risk characteristics for recurrence, so he received adjuvant therapy with imatinib for 3 years. In 2018, 3 years after completing the adjuvant therapy, tumor lesions at residual gastric cardia were incidentally identified by follow-up computed tomography (CT). The pathological findings of the tumor biopsy revealed gastric GIST. He underwent secondary laparoscopic partial gastrectomy and was diagnosed with high-risk GIST. Adjuvant therapy with imatinib was restarted immediately. The two gastric GISTs had the same exon 11 mutations in the c-kit gene, but they had different missense mutations. This molecular heterogeneity suggested that they were derived from different origins. Conclusion: We reported a multiple heterochronic GIST in the stomach detected 6 years after resection. There may be a possibility that another heterochronic GIST will occur in the remnant stomach in the future, so close follow-up will be needed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink