| Autor: |
Shah, Mudassir, Sun, Chunxiao, Sun, Zichao, Zhang, Guojian, Che, Qian, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai |
| Zdroj: |
Marine Drugs; Feb2020, Vol. 18 Issue 2, p71, 1p |
| Abstrakt: |
Three new polyketides, ketidocillinones A–C (1–3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1−3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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