| Autor: |
Prozorovskii, V. N., Ipatova, O. M., Tikhonova, E. G., Zakharova, T. S., Druzhilovskaya, O. S., Korotkevich, E. I., Torkhovskaya, T. I. |
| Zdroj: |
Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Jan2020, Vol. 14 Issue 1, p78-81, 4p |
| Abstrakt: |
Besides application of newly developed pharmacological agents many therapeutic schemes employ known effective drugs, particularly glucocorticoids. Prednisolone, one of the most commonly used glucocorticoids, is characterized by pronounced anti-inflammatory activity. Its major disadvantage consists in short-term circulation in the blood and the need of repeated injections, which can cause side effects. In this regard, many attempts are undertaken to develop more effective and safer dosage forms of this drug substance. We have obtained a prednisolone composition incorporated into nanoparticles of soybean phosphatidylcholine with an average diameter of 20 nm. The oral administration of this composition in rats increased maximal prednisolone concentrations in plasma and duration of its circulation as compared with administration of the free drug substance. In mice with a model of inflammation induced by subplantar injection of conconavalin A, the index of the inflammation reaction (determined by paw edema) decreased in the case of the prednisolone composition in nanoparticles significantly more actively than after administration of the free drug substance: the maximum index decrease (62.2% compared to 49.6%) was observed already at the minimum dose of prednisolone administered (2.5 mg/kg), free drug substance at this dose was ineffective. The results indicate an increase in the effectiveness of prednisolone incorporated into phospholipid nanoparticles; this makes it possible to reduce the administered dose and the risk of side effects as well. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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