Interleukin-36γ Is Elevated in Cervicovaginal Epithelial Cells in Women With Bacterial Vaginosis and In Vitro After Infection With Microbes Associated With Bacterial Vaginosis.

Autor:	Gardner, Jameson K, Łaniewski, Paweł, Knight, Anna, Haddad, Lisa B, Swaims-Kohlmeier, Alison, Herbst-Kralovetz, Melissa M
Předmět:	BACTERIAL vaginitis EPITHELIAL cells BACTERIAL cells SEXUALLY transmitted diseases MICROORGANISMS RESEARCH CELL culture RESEARCH methodology INTERLEUKIN-1 EVALUATION research MEDICAL cooperation CERVIX uteri VAGINA NEUTROPHILS COMPARATIVE studies GENES BACTERIA
Zdroj:	Journal of Infectious Diseases; 3/15/2020, Vol. 221 Issue 6, p983-988, 6p
Abstrakt:	In recent studies, the interleukin (IL)-36 cytokines were shown to be elevated in women with non-Lactobacillus-dominated vaginal microbiomes. In this study, we evaluated IL36G expression in clinical samples from women with and without bacterial vaginosis (BV) and a human 3-dimensional cervical epithelial cell model. IL36G expression was significantly elevated in cervicovaginal epithelial cells isolated from BV-positive women and corresponded with increased neutrophil counts relative to BV-negative women. In addition, specific BV-associated bacterial species as well as a polymicrobial cocktail significantly induced IL36G expression in vitro. These findings suggest that IL-36γ may exhibit an important function in the host response to BV and other sexually transmitted infections. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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