| Autor: |
Schulze, S., Niggemann, B., Savaser, A. N., Wahn, U. |
| Předmět: |
|
| Zdroj: |
Allergy; Dec92, Vol. 47 Issue 6, p644-649, 6p |
| Abstrakt: |
In order to establish a noninvasive method of monitoring immediate hypersensitivity reactions in children, we studied the diurnal variation of urinary histamine and 1-methylhistamme excretion and the influence of food intake in a group of 14 healthy nonalopic children (aged 2-16 years) Histamine and 1-methylhistamine in spontaneous urine samples were determined by radioimmunoassay. Mean variation of 2-h intervals was much higher for urinary histamine than for 1-methylhistamine (45% of base-line level versus 24%) There was no circadian rhythm or influence of food intake The short half-life of histamine released into blood circulation may be tile main reason for the higher variation of histamine excretion In children, urinary 1-methylhistamine is less influenced by diurnal variation and is therefore more suited to monitor immediate hypersensitivity reactions than urinary histamine itself. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text