| Autor: |
Bou Jawde, Samer, Takahashi, Ayuko, Bates, Jason H. T., Suki, Béla |
| Předmět: |
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| Zdroj: |
Frontiers in Physiology; 2/25/2020, Vol. 11, p1-11, 11p |
| Abstrakt: |
The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to be an emergent phenomenon arising from the ensemble behavior of its microscopic constituents. Such behavior includes the alignment and elongation of randomly oriented alveolar walls with initially flaccid fibers in the direction of strain. To account for the link between microscopic wall behavior and the macroscopic stress-strain curve, we developed an analytical model that represents both alignment and elongation of alveolar walls during uniaxial stretching. The model includes the kinetics and mechanical behavior of randomly oriented elastic alveolar walls that have a bending stiffness at their intersections. The alignment and stretch of the walls following incremental stretch of the tissue were determined based on energy minimization, and the total stress was obtained by differentiating the total energy density with respect to strain. The stress-strain curves predicted by the model were comparable to curves generated by a previously published numerical alveolar network model. The model was also fit to experimentally measured stress-strain curves in parenchymal strips obtained from mice with decreased lung collagen content, and from young and aged mice. This yielded estimates for the elastic modulus of an alveolar wall, which increased with age from 4.4 to 5.9 kPa (p = 0.043), and for the elastic modulus of fibers within the wall, which increased with age from 311 to 620 kPa (p = 0.001). This demonstrates the possibility of estimating alveolar wall mechanical properties in biological soft tissue from its macroscopic behavior given appropriate assumptions about tissue structure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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