MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression.

Autor: Campos-Viguri, Gabriela Elizabeth, Peralta-Zaragoza, Oscar, Jiménez-Wences, Hilda, Longinos-González, Alma Edith, Castañón-Sánchez, Carlos Alberto, Ramírez-Carrillo, Miriam, Camarillo, César López, Castañeda-Saucedo, Eduardo, Jiménez-López, Marco Antonio, Martínez-Carrillo, Dinorah Nashely, Fernández-Tilapa, Gloria
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Zdroj: Scientific Reports; 2/24/2020, Vol. 10 Issue 1, p1-14, 14p
Abstrakt: Malignant transformation and progression in cancer is associated with the altered expression of multiple miRNAs, which are considered as post-transcriptional regulators of genes participating in various cellular processes. Although, it has been proposed that miR-23b-3p acts as a tumor suppressor in cervical cancer (CC), not all the pathways through which it alters the cellular processes have been described. The present study examines whether miR-23b-3p directly represses the c-Met expression and that consequently modifies the proliferation, migration and invasion of C33A and CaSki cells. c-Met has five microRNA response elements (MREs) for miR-23b-3p in the 3′-UTR region. The ectopic overexpression of miR-23b-3p significantly reduces c-Met expression in C33A and CaSki cells. The overexpression of miR-23b-3p reduces proliferation, migration and invasion of CaSki cells and the proliferation and invasion in C33A cells. In CaSki cells, the activation of Gab1 and Fak, downstream of c-Met, is reduced in response to the overexpression of miR-23b-3p. Together, the results in the present study indicate that miR-23b-3p is a tumor suppressor that modulates the progression of CC via post-transcriptional regulation of the c-Met oncogene. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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