Blood cell for the differentiation of airway inflammatory phenotypes in COPD exacerbations.

Autor:	Gao, Jie, Chen, Bida, Wu, Sifang, Wu, Feng
Předmět:	BLOOD cells CELL differentiation CELL analysis OBSTRUCTIVE lung diseases PULMONARY function tests HYPEREOSINOPHILIC syndrome OBSTRUCTIVE lung disease diagnosis EOSINOPHILS DISEASE progression INFLAMMATION SPUTUM DIFFERENTIAL diagnosis RETROSPECTIVE studies LYMPHOCYTES NEUTROPHILS LEUKOCYTE count MONOCYTES PHENOTYPES
Zdroj:	BMC Pulmonary Medicine; 2/24/2020, Vol. 20 Issue 1, p1-9, 9p, 3 Charts, 3 Graphs
Abstrakt:	Background: Measurement of sputum is frequently used to define airway inflammatory subtypes. The venous blood cell is a reliable and simple biomarker, may be used as an alternative procedure to reflect the subtypes. For the aim of verifying the hypothesis that venous blood cell can quantify sputum inflammatory cell to access the airway subtypes in chronic obstructive pulmonary disease of acute exacerbations (AECOPD) and to ascertain the accuracy of the blood cell biomarker.Methods: This study evaluated 287 patients with COPD exacerbations and all four tests were performed on the same day, which are lung function test, bronchodilator reversibility test, sputum cell analysis and blood routine examination.Results: There was a correlation between sputum eosinophils and blood eosinophils, blood cells derived ratios. There was a weaker relationship to neutrophils between sputum and blood. Sputum neutrophils had not any association with neutrophil/macrophage ratio (NMR) and eosinophil/lymphocyte ratio (ELR) in blood. Blood eosinophils percentage was predictive for eosinophilic COPD exacerbations with an area under the curve (AUC) of 0.672 (p = 0.012). The optimum cutpoint for blood eosinophils percentage was 0.55%. Blood eosinophils absolute count was also predictive sputum eosinophilia at 0.35 × 109/L (AUC = 0.626, p = 0.025). ELR, eosinophil/monocyte ratio (EMR) and eosinophil/neutrophil ratio (ENR) in blood were higher in COPD exacerbations with mixed granulocytic and eosinophilic subtypes.Conclusion: Eosinophils/neutrophils count parameters were relationship between blood and sputum. Eosinophils in blood and the ratios (ENR, EMR and ELR) may be utilized to assess eosinophilic airway inflammation in COPD exacerbations. Due to weak relationship and poor predictive ability, more researches should be required. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink