| Autor: |
Chernyshov, Vladimir V., Yarovaya, Olga I., Fadeev, Dmitry S., Gatilov, Yuriy V., Esaulkova, Yana L., Muryleva, Anna S., Sinegubova, Katherina O., Zarubaev, Vladimir V., Salakhutdinov, Nariman F. |
| Zdroj: |
Molecular Diversity; Feb2020, Vol. 24 Issue 1, p61-67, 7p |
| Abstrakt: |
An effective technique for one-stage synthesis of new polycyclic nitrogen-containing compounds has been developed. The procedure involves refluxing mixtures of camphoric acid with aliphatic or aromatic diamine without catalysts. In cases where the starting amine has a low boiling point (less than 200 °C), phenol is used as a solvent, as it is the most optimal one for obtaining products with good yields. It has been shown that the use of Lewis acids as catalysts reduces the yield of the reaction products. A set of compounds have been synthesized, which can be attributed to synthetic analogues of alkaloids. In vitro screening for activity influenza virus A was carried out for the obtained compounds. The synthesized quinazoline-like agent 14 has inhibitory activity against different strains of influenza viruses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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