| Autor: |
LIU Hong-yu, YU Xin-guang, CHEN Ling |
| Předmět: |
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| Zdroj: |
Chinese Journal of Contemporary Neurology & Neurosurgery; Feb2020, Vol. 20 Issue 2, p111-118, 8p |
| Abstrakt: |
Malignant glioma is the most highly invasive primary brain tumor associated with an extremely poor prognosis and median survival of only 14.6 months. An improved treatment for glioblastoma is urgently needed. Unique to oncolytic viruses (OVs) is the ability of the virus to infect specifically a tumor cell and induce tumor lysis through the release of viral progeny, which can subsequently infect nearby tumor cells. Several OVs proved their safety and efficacy in several preclinical studies. In this review, we report the OVs that successfully transferred into the clinical trials. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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