| Autor: |
K. C., Nikhil, Pruthviraj, D. R., Aderao, Ganesh N., Harish Kumar, K. P. |
| Předmět: |
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| Zdroj: |
Journal of Experimental Zoology India; Jan2020, Vol. 23 Issue 1, p1-12, 12p |
| Abstrakt: |
CRISPR-Cas system acts as genetic vaccination record by integration of invading viral DNA into the CRISPR loci of bacterial genome which gives protection to the host by cleaving invading viral DNA in subsequent infections. There are mainly three types of CRISPR-Cas systems of which type II CRISPR-Cas system is used as a genome editing tool because of its simplicity, specificity and efficiency. The CRISPR-cas9 genome editing system is a promising method to bring genetic improvement in animal health and productivity. It is also used in various applications including reverse genetics studies to understand the role of specific genes, genome recoding, for disease modelling, and for demonstrating new therapies in a number of cancers as well as genetic and infectious diseases using transgenic organisms. Although, a number of genome editing tools are available currently, CRISPR-Cas9 genome editing system is considered to be the most efficient because it targets multiple loci at a time. Here, an attempt has been made to review various tools available for genome editing with special emphasis on the progress made in CRISPR-Cas9 system till date. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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