| Autor: |
KS, Kelly-sprau, KE, Gurley, Y, Yasui, CJ, Kemp |
| Předmět: |
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| Zdroj: |
PLoS Biology; Aug2004, Vol. 2 Issue 8, p1046-1046, 1p |
| Abstrakt: |
The article focuses on deterministic tumor evolution. The essential difference between cancer cells and normal cells is that cancer cells evolve. Most cancers arise from a single cell through a sequential evolutionary process of mutation and selection. Cancer cells harbor mutations in a number of critical genes that, at various stages during the evolution of the tumor, provide those cells with a selective advantage. Many of the phenotypes, or physical outcomes, conferred by these mutant genes are subverted from a normal cell's repertoire. Tumor evolution is thought to adhere to Darwinian principles, with mutations arising randomly within an individual cell, followed by selection for mutant clones with favorable traits. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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