Polymeric worm-like nanomicellar system for accelerated wound healing.

Autor: Singh, Aarti, Shakeel, Adeeba, Kochhar, Dakshi, Jeevanandham, Sampathkumar, Rajput, Satyendra, Mukherjee, Monalisa
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Zdroj: Journal of Advanced Pharmaceutical Technology & Research; Jan-Mar2020, Vol. 11 Issue 1, p36-43, 8p
Abstrakt: Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems – a material with ample potential for wound healing applications – to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (DEAEMA-co-AAc) (PDEA) is examined with a cutaneous excisional wound model alterations in wound size, and histological assessments revealed a higher wound healing rate, including dermis proliferation, re-epithelialization, reduced scar formation, and anti-inflammatory properties. Moreover, a mechanism for the formation of spherical and worm-like micelles (WLMs) is delineated using a suite of characterizations. The excellent porosity and ability to absorb exudates impart the PDEA with reliable wound healing. Altogether, this system demonstrates exceptional promise as an infection-mitigating, cell-stimulating, homeostasis-maintaining dressing for accelerated wound healing. The aim and objective of this study is to understand the mechanism of self-assembly in synthesized WLMs from PDEA and their application in wound healing. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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