| Autor: |
Nkenfou, Celine Nguefeu, Abange, William Baiye, Gonsu, Hortense Kamga, Kamgaing, Nelly, Lyonga, Emilia Mbamyah, Dieu Anoubissi, Jean de, Ndjolo, Alexis, Koki, Paul |
| Předmět: |
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| Zdroj: |
Pan African Medical Journal; Sep-Dec2019, Vol. 34, p1-9, 9p |
| Abstrakt: |
Introduction: HIV infection is characterized by changes in the composition and functions of gut microbiota. We carried out a study aiming at comparing the compositional changes of the digestive flora of HIV infected infants versus that of non infected infants in Cameroon. Methods: a case-control study was carried out during which stool sample was collected from each participant after obtaining the proxy consent . Stools were cultured using aerobic, strict anaerobic, 10% CO2 and micro-aerophilic conditions and specific culture media and bacteria were identified biochemically. Fisher's exact test was used for data analyses. Results: from the 80 infants enrolled for the study, 33 (41.3%) were HIV positive. A statistically significant difference was observed between the number of infected versus non infected infants harboring the following bacteria: Clostridium spp. (P=0.009); Enterococcus spp. (p<0.001); Klebsiella (p<0.001); Shigella (<0.001); Staphylococcus aureus (p=0.006) and Streptococcus spp. (P=0.015). Among infected infants, WHO-stage 3 and 4 infants harbored more opportunistic bacteria than stage 1 and stage 2 and Bacteriodes spp. population was depleted as the disease progresses, although not significantly. There was an imbalance in bacteria flora in HIV infected infants harboring qualitatively more bacteria including more opportunistic and pathogenic bacteria than in HIV non-infected infants. Conclusion: HIV infected infants presented a qualitatively different flora from HIV non infected infants. They habored more pathogenic bacteria than non infected infants. Systematic stool culture could benefit for follow-up of HIV infected infants to reduce the risk of gastrointestinal disorders and thus the risk of high morbidity or high mortability. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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