Screening of Nutraceuticals and Plant Extracts for Inhibition of Amyloid-β Fibrillation.

Autor:	Witter, Steffi, Samoson, Ago, Vilu, Raivo, Witter, Raiker
Předmět:	PLANT extracts CENTELLA asiatica FUNCTIONAL foods FLUORESCENCE spectroscopy ALZHEIMER'S disease AMYLOID plaque PROTEIN metabolism PROTEINS RESEARCH RESEARCH methodology MEDICAL cooperation EVALUATION research PLANTS HYDROCARBONS DIETARY supplements COMPARATIVE studies PEPTIDES
Zdroj:	Journal of Alzheimer's Disease; 2020, Vol. 73 Issue 3, p1003-1012, 10p
Abstrakt:	Fluorescence spectroscopy for in vitro amyloid-β (Aβ) fibrillation diagnosis and spectral fluorescence signature for the identification of bioactive compounds were applied to study traditional Ayurvedic nutraceuticals - Brahmi, Ashwagandha, Shanka pushpi, and Gotu kola - as well as their plant extracts for possible treatment of Alzheimer's disease. All samples manifest as inhibitors on three different variants of the Aβ peptide: methionine Aβ1-40, Aβ1-40, and Aβ1-42. The main compounds within the nutraceuticals were identified. Since related medicals are known to have reduced negative post- and side-effects and even may introduce further positive health impacts by preventing pathogen plaque formation and reducing free Aβ to a natural level, such treatment approaches could be of further interest. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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