| Autor: |
Wilson, Hugh M., James P. Wilson, Paul E. Slaton, John H. Foster, Grant W. Liddle, John W. Hollifield, Wilson, H M, Wilson, J P, Slaton, P E, Foster, J H, Liddle, G W, Hollifield, J W |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; Jul77, Vol. 87 Issue 1, p36-42, 7p |
| Abstrakt: |
Saralasin, an angiotensin II antagonist, was infused into 49 patients with renal artery stenosis, 10 patients with essential hypertension and normal renal arteriograms, and five patients with "low-renin essential hypertension." Renal venous renin and differential renal function studies were used to assess the functional significance of arterial stenoses. "Response" to saralasin, evidenced by a fall in blood pressure during infusion, occurred in no patients with "low renin" hypertension and in only 20% of patients with normal renal arteriograms. In contrast, saralasin "response" occurred in more than 80% of patients with renal artery stenosis and lateralizing functional studies and 100% of cases of "proven" renovascular hypertension (cure or improvement of hypertension after operative treatment). We suggest that saralasin infusion might be a valuable screening test for the recognition of renovascular hypertension. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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