| Autor: |
Dy, Frederick, Navarroza, Ann Margaret, Evangelista Guzman, Maria Roselle, Chan, Melchor, Dalupang, Carmelita, Romano, Rommel |
| Předmět: |
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| Zdroj: |
Gut & Liver; Nov2019, Vol. 13 Issue 6(suppl. 1), p128-128, 1/4p |
| Abstrakt: |
Background/Aims Eradication of Helicobacter pylori has become interest for research for the optimal regimen which are composed of both antibiotics and gastric acid-reducing agents as a standard of treatment. Challenges arise from bacterial antibiotic resistance, lack of follow-up to confirm treatment success/failure, as well as poor compliance due to adverse effect and high pill burden. This study aims to compare the efficacy of triple therapy versus concomitant therapy in eradicating H. pylori infection. Methods This is a prospective, open label, randomized controlled trial wherein 110 subjects with symptoms of dyspepsia and esophagogastroduodenoscopy findings of peptic ulcer disease or gastritis were enrolled. The diagnoses of H. pylori infection were confirmed using rapid urease test, histology or Giemsa stain. Patients with previous H. pylori eradication therapy, allergies to medications used, previous gastric surgery, presence of serious comorbidities and pregnant women were excluded from the study. Patients were randomized to triple therapy (40 mg omeprazole, 500 mg clarithromycin, and 500 mg two capsule amoxicillin twice daily for 14 days) or concomitant therapy (40 mg omeprazole, 500 mg clarithromycin, 500 mg two capsule amoxicillin, and 500 mg metronidazole twice daily for 14 days). H. pylori infection eradication were determined using stool antigen testing after a month free of antibiotics and proton pump inhibitor. Results The eradication rate of each therapy was evaluated by intention-to-treat and per-protocol analyses. Eighty-five percent eradication rate of H. pylori was achieved with CT (compared to 71.05% in TT) was significant with a p-value of 0.0386. Lower adverse effect profile (45.5% vs 69.7%, p=0.0274) and higher compliance rate (88.63% vs 82.6%, p=0.0441) were also noted. Conclusions The eradication rate for the concomitant therapy was much higher than those of the standard triple therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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