| Autor: |
Pons, Maria Carme, Carrasco, Beatriz, Parriego, Mònica, Boada, Montserrat, González-Foruria, Iñaki, Garcia, Sandra, Coroleu, Buenaventura, Barri, Pedro N., Veiga, Anna |
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| Zdroj: |
Journal of Assisted Reproduction & Genetics; Nov2019, Vol. 36 Issue 11, p2299-2305, 7p |
| Abstrakt: |
Purpose: To determine the developmental competence of fast-cleaving D3 embryos. Methods: Retrospective study including 4028 embryos from 513 PGT-A cycles performed between July 2014 and June 2017. Embryos were cultured in time-lapse incubators and biopsied at blastocyst stage. Embryos were classified in groups according to the number of cells on D3 (from 2-cell to ≥13 -cell and compacted). A generalized linear mixed model adjusted for confounding factors was performed to assess the chance to give rise to an euploid blastocyst in each group compared with the chance of 8-cell embryos. Implantation and live birth rates were also analyzed. Results: The statistical analysis showed that embryos with 9 to 11 cells had a slightly lower euploid blastocyst rate than 8-cell embryos (OR (95% CI) 0.77 (0.61–0.96)) while embryos with more than 11 cells were found to be just as likely to give rise to an euploid blastocyst as the 8-cell embryos (OR (95% CI) 1.20 (0.92–1.56)). Conversely, slow-cleaving embryos had a significantly lower euploid blastocyst rate than 8-cell embryos (OR (95% CI) 0.31 (0.24–0.39)). Moreover, euploid blastocysts derived from fast-cleaving embryos and from 8-cell embryos exhibit similar live birth rates. No significant differences were found in the chance to give rise a live birth between 8-cell and 9- to 11-cell embryos (OR (95% CI) 1.23 (0.70–2.15)) and > 11-cell embryos (OR (95% CI) 1.09 (0.57–2.09)). Conclusions: Embryos with more than 11 cells exhibit similar developmental competence to 8-cell embryos. Their poor prognosis should be reconsidered. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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