| Autor: |
PAKKI, ERMINA, ALAM, GEMINI, USMAR, SYUKUR, RAHMAWATI, MUSLIMIN, LUKAAAN |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical Research (09752366); 2019 Supplement, Vol. 11, p602-608, 7p |
| Abstrakt: |
Introduction: Natural products are well recognised as sources of drugs in several human ailments. Purpose: In the present work was carried out a preliminary screening of 32 medicinal plants indigenous to Duri Ethnic against HeLa cell lines. Method: In addition, the extracts were tested for their selectivity towards cancer cells (HeLa) as compared to normal cells (Vero). The toxicity was tested by MTT assay in both cancer and normal cells at various concentrations. The extracts exhibited dose-dependent cytotoxicity in both cells with varying indices of selectivity index (SI). Result: The results obtained indicate that only 4 plants have a tremendous anticancer activity (IC50 < 50.00 pg/mL): Annona squamosa, Areca catechu, Macrosolen cochinchinensis, and Piper caducibracteum. While selectivity was only found to be most favourable in A. catechu (Sl= 1.24). Value: The overall results of the present study provided evidence for the anticancer activity of A. catechu and bring supportive data for future investigations that effective and safety in cancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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