Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia.

Autor:	Eckerström, Carl, Eckerström, Marie, Göthlin, Mattias, Molinder, Anna, Jonsson, Michael, Kettunen, Petronella, Svensson, Johan, Rolstad, Sindre, Wallin, Anders
Předmět:	TRAIL Making Test VASCULAR dementia DEMENTIA COGNITIVE testing ALZHEIMER'S disease NEUROPSYCHOLOGICAL tests DIAGNOSIS of dementia ALZHEIMER'S disease diagnosis BRAIN REFERENCE values RESEARCH NERVE tissue proteins RESEARCH methodology COGNITION DIFFERENTIAL diagnosis MAGNETIC resonance imaging EVALUATION research COMPARATIVE studies PEPTIDES LONGITUDINAL method
Zdroj:	Journal of Alzheimer's Disease; 2020, Vol. 73 Issue 2, p597-607, 11p
Abstrakt:	Background: Research has shown that mixed dementia is more common than previously believed but little is known of its early stages.Objective: To examine if incipient mixed dementia can be differentiated from incipient Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SVD) using neuropsychological tests, cerebrospinal fluid (CSF) markers, and magnetic resonance imaging markers.Methods: We included 493 patients and controls from the Gothenburg MCI study and used the dementia groups for marker selection (CSF total-tau (T-tau), phospho-tau (P-tau), and amyloid-β42 (Aβ42), 11 neuropsychological tests, and 92 regional brain volumes) and to obtain cut-off values which were then applied to the MCI groups.Results: Incipient mixed dementia was best differentiated from incipient AD by the Word fluency F-A-S test and the Trail making test A. CSF T-tau, P-tau, and Aβ42 differentiated incipient mixed dementia from incipient SVD.Conclusion: Incipient mixed dementia is characterized by an AD-like biomarker profile and an SVD-like cognitive profile. Incipient mixed dementia can be separated from incipient AD and incipient SVD using CSF markers and cognitive testing. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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