| Autor: |
Basyte-Bacevice, Viktorija, Kupcinskas, Juozas |
| Předmět: |
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| Zdroj: |
Digestive Diseases; 2020, Vol. 38 Issue 2, p137-142, 6p, 2 Diagrams |
| Abstrakt: |
Discovery of hepatitis C in 1989 allowed basic research to identify critical components of hepatitis C virus (HCV) structure and life cycle. Interferon (IFN)-α was introduced as first treatment for chronic hepatitis C and later was enhanced by pegylation, addition of ribavirin, and resulted in improved sustained virologic response. Better understanding of HCV structure, enzymes, and lifecycle led to the discovery of direct-acting antivirals and IFN-free era. Successful HCV therapy created a rare possibility of global disease eradication, which is now a major goal internationally. However, hepatitis C remains a major public health challenge, and more resources are needed to reach global elimination. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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